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To view a copy of this licence, visit About this article Cite this article DAmbrosio, M., White, M.E.H., Gavriil, E.S

More importantly, PKM2 can translocate into the nucleus, where it regulates the transcription of metabolic genes such as HIF-1, LDHA, and GLUT1, thereby enhancing glycolysis, suppressing OXPHOS, and establishing a metabolic firewall against therapeutic stress [97]